From Amarillo to Detroit / Windsor took me three comfortable days travel. Two days if you don't mind long days on the road, and one day if you drive straight through.
The shortest time is 1 hour. This is the best route: Take U.S. 385 SOUTH to LOOP 338 in the northern edges of Odessa. Turn left. Take LOOP 338 around Odessa to either TX-191 EAST or I-20 EAST. Take...