If its from the airport Bear in mind that it may take you an hour to get across Mexico City from the airport (which is truly a horrendous journey). and then a minimum 5 hours to Guadalajara. I would...
Greater Mexico City spans about 40 Kilometers. On a Sunday morning between 3 to 6 AM you can take between one hour to one hour and a half to cross the city on car. If you add traffic and/or rain, it...