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Many dermatologists actually recommend staying away from neosporin on fresh surgical sites because of the high incidence (around 10%) of people who have a reaction to it. However, if you choose to use it and don't have any problems with it, it would be best to use until the site is healed over. The main benefit you get from it is that it keeps the fresh site moist, which aids in healing. In actuality, you don't need any antibiotic for a small punch biopsy, unless you have any complicating medical conditions. The best thing to use on any healing wound is vaseline (best because it lacks any additives that may irritate the skin) a couple of times a day to keep it moist during healing. But of course, any specific questions about YOUR biopsy site should be directed back to your doctor -- most can answer a question like that on the phone or email. Hope that helps! Here's a link to a recent article discussing the use of topical antimicrobials on fresh surgical sites: http://www.ncbi.nlm.nih.gov/pubmed/18674453?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

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Q: How long should you apply neosporin to a punch skin biopsy site?
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