I had my gallbladder removed a month ago. They told me before I left the hospital not to drink for 24 hours - ha! Like I felt like drinking! However, your body may take longer to tolerate it. I tried last week to drink a glass of wine. After a few sips, I had a buzz and was not feeling very well. A couple nights later while spending the evening with a few friends, I had 2 glasses of wine. The next day I had the worst hangover of my life ( I am not prone to hangovers and while I don't drink heavily, it takes more than 2 glasses of wine to give me one). I was very sick to my stomach for the rest of the next day. So my advice would be to wait until you are recovered from surgery (and off any prescription pain medications) and take it slowly, to see what your body can handle. I did a little research to find out if it's normal to have problems drinking alcohol after this surgery, and it seems to be a lot of people who have trouble. Well, at least it wasn't the flu like I thought!