How many 500mg Tylenol pills would equal the relief of one Vicodin pill?

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Acetaminophen Vi codan

Regarding the ? of equigesic aspects your question poses qualities which raise "Red Flags" to me.As Vicodin is indicated for : mod-sev pain of non-neurological etiology and Acetaminophen is a med used for mild-mod pain not caused by an inflammatory condition and also as an antipyretic med(lowers fever); The two drugs act quite differently. The answer to your ? is: 3-8 grams.This equals 6-16 tabs. The difficulty your ? poses in an ethical sense is that the L.D 50(the lethal dose of Tylenol which would prove fatal to 50% of users)is 9.5 Grams. The reason I'd advise against using large doses of Tylenol is ,Too much will cause liver necrosis.The risks far outweigh the benefits in this case. The tone of your ? indicates to me that you're wishing to control mod-sev pain with massive amounts of Extra-Strength Tylenol as you may not be able to access or use Vicodin.Needing as much as 8 gs' is dangerously close to the lethal o.d. value of 9.5gs'. I am a Paramedic,not a physician,but I must tell you that the amount of Tylenol you would have to take would exceed current safety guidelines and my advice is to save your Liver.Acute Acetaminophen o.d.s' are fatal due to hepatic(liver) failure due to acetaminophens' being converted by the cytochrome P450 System to a toxic metabolite that is subsequently conjugated with glutathione and excreted by the kidneys.However,when glutathione is depleted following a high dose of acetaminophen,the toxic metabolite accumulates and is thought to be the cause of acetaminophen=induced liver necrosis. Hope this helps, Dave Hobbins-E.M.T.-A-P

First answer by ID1179127146. Last edit by ID1179127146. Question popularity: 35 [recommend question]