In shelters alone, approximately 3-4 million cats and dogs are euthanized every year. It is hard to get a completely accurate answer, because not all shelters report, or are required to report all euthanasias. These numbers are from the Humane Society Website. "The HSUS estimates that animal shelters care for between 6-8 million dogs and cats every year in the United States, of whom approximately 3-4 million are euthanized. At this time The HSUS can only estimate these figures because there is no central data reporting agency for animal shelters. This overpopulation of companion animals is widely acknowledged across the country by professionals and experts in the animal welfare field. Overpopulation is a tragedy. There are simply not enough responsible homes for all of these wonderful, innocent animals. At this point in time, it would be impossible to humanely house every unwanted animal in the United States.
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Millions! If you mean lost, like going to doggie heaven, then that's a lot! There are lots of high-kill shelters that put up to 10 dogs to sleep a day(euthanasia), and there are also a lot of dogs that die from other things like getting run over or diseases or just old age. If you mean like accidentally straying from home, then there's a few hundred thousand dogs.