How many presidents were assassinated while in office?

Answer:

Four U.S. Presidents have been assassinated while in office:
Abraham Lincoln in 1865 by John Wilkes Booth
James Garfield in 1881 by Charles J. Guiteau (Guiteau shot him but Garfield arguably died due to subsequent incorrect medical care)
William McKinley in 1901 by Leon Czolgosz
John F. Kennedy in 1963 by Lee Harvey Oswald

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