It depends on which way you go. There are ways to avoid almost all the tolls, but it will increase the trip time. To minimize tolls and still make the trip quickly, try this route: From Manhattan,...
On the I-90, or the New York State Thruway, assuming you have a standard vehicle:
Tolls from Exit 23 - Albany (Downtown) to Exit 53 - Buffalo (Downtown) - I-190
Cash: $10.85
With EZPASS:...