The dosage of fluoxetine hydrochloride required for an overdose depends both on the mass of the person in question and how long that person has been taking the drug. For approximately four weeks, the level of fluoxetine in the bloodstream increases, as its presence inhibits its own metabolization. This decreases the amount of fluoxetine required to reach a level associated with adverse effects.
The lowest known dosage of fluoxetine hydrochloride associated with death was 520 mg. However, the actual cause of death in this case was not confirmed to be overdose. On the other hand, the largest known overdose of only fluoxetine hydrochloride was 8 full grams. This patient subsequently made a full recovery.
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