I first bathed my APBT puppy at 10 weeks. Make sure that it isn't within the first few weeks of any surgery (i.e. spay/neuter) so it doesn't dissolve the stitches or cause infection. Do not over...
Puppies should get their first set of shots at 8 weeks old, the second set at 12 weeks and their final shots at 16 weeks, at which point they are old enough to also be spayed or neutered.
The mother dog keeps the puppies clean until they are around 6 - 8 weeks old. After that time, she has already begun weaning them, and is not cleaning them as she did when they were newborns.
So...