yes. In Hermesetas you can find - cyclamate : banned in the US since 1970 - saccharine : also with negative side effects on health (1) (1) See the answer to the question about cyclamate side effects...
In a Washington Post article, dated May 17, 1989, (author Malcolm Gladwell) writes that use of sodium cyclamate (SC) was found by researchers to "damage chromosomes of cells growing in laboratories,...