If you are fairly sure your wife has cheated on you should you confront her?

Answer

You must have proof or what you asked her will be back fired and she will deny the whole thing. But if you have proof and no for certain, leave him. He will continue to do that and you do not want to get hurt. I had a boyfriend that got my best friend pregnant and left her and came back begging to me because i broke up with him after i heard about it. My ex best friend cried to me and said 'im sorry, i didn't mean too..' I told her 'F*** you. You are a b***h, you do not deserve to be in my sight. Get out of my face.' Then i slapped her across her face, She cried and kept apologizing, i slapped her again. 'Shut up.' She still tired. Again, i slapped her. 'I have nothing to say to you.' I then walked away. It was a very disgusting day for me. Don't end up like that, confront him with proof and stand your ground. Don't get weak knees, stand tall. Tell him your threw and he made you fall. Dump him.  

Answer

Only if you have some proof otherwise it will be total denial. My husband just had an affair for two years, with a married woman. I suspected it all along, but he constantly denied it to me, and she denied it to her husband. Finally, after finding a detailed love letter signed by her in my husband's briefcase, I called her husband, met him and gave him the letter. It was really a signed confession. So if you have any evidence whatsover, yes you should say something or it will just go on, and on.  

Answer

Yes, but you need to ask yourself if you are willing to save this marriage (if your wife admits to and ends the affair, goes to counseling) or if you will get a divorce. This is going to be even tougher if you have children together.
If you have kids, don't have this talk with your wife when they are around. Try to keep this from your kids as much as you can, even though they may have to deal with their parents splitting up. If you decide to do that, try to be as amicable with your wife as possible--don't show hatred or vent your emotions with your kids around.
I agree with the previous poster: your wife might still deny the affair. If that happens, you need to make a decision about whether to stay married or not.