I believe if you are able to hold the skunk's hind legs off the ground, (by the tail, careful they can still bite) it will not be able to squeeze the gland holding the spray.
There is a gland in the anus that holds the spray for when it is needed. The spray is not pee. It is a special oily concoction that is made for the express purpose of deterring preditors. Actually,...
they have a special liquid near where their feces come out, and when they feel threatened or frightened, they spray it and once they use it all up, their body produces more.