If you wanted to block cAMP signaling by targeting PKA what might you do that would block PKA activity?
pKa is the acid dissociation constant for any acid. It is a measure of strength of the acid.
The pKa value for sodium bicarbonate (NaHCO3) is 10.3. This provides a measure of the acid strength of bicarbonate. People often make the mistake of reporting the pKa value… of 6.3 for bicarbonate. However, that is the pKa value of carbonic acid (not bicarbonate). It relates to the ease of the first deprotonation of carbonic acid to form bicarbonate. The pKa of bicarbonate relates to the deportation of bicarbonate to form carbonate. This distinction is important, since carbonic acid has two pKa's, the higher of which represents that second deprotonation.
pKa1 = 2.16 pKa2 = 8.05 Ref: Newton, D.W., Murray, w.j., Lovell, M.W. pKa Determination of benzhydrylpiperazine antihistamines in aqueous and aqueous methanol solutions (1982…) Journal of Pharmaceutical Scienses 71 (12), pp. 1363-1366
10.19 at 25 degrees Celsius
pKa is measured for acid in aqueous solution while hexane is an organic liquid immiscible with water so pKa value is meaning less for hexane.
PKA means Protein Kinase A Pathway found in Yeat, S. cervisiae.
pKa of HCHO 2 , formic acid, methanoic acid, is 3.80