Answer:
Yes and no. Some claim that it is, as it involves Mr. and Mrs.Murry, and Meg's old house as well as the people (and Louise the Snake) from the other books. But it can be said that it is part of another series, the series about Polly O'Keefe. In all of Madeleine L'Engle's children's books, characters seem to keep on popping up in different series!