Answer:
Not really! It's 16 hours on a direct route (by bus it could be a little longer). The distance between the two cities is only around 700 miles (1126 km), but the terrain is really windy and mountainous once you get past Ica en route.
Alternatively, there is the slightly safer route via Arequippa, but this takes an extra two hours (as it is further) and is not as scenic (though Arequippa is very pretty and worth visiting itself).
Also, you can fly between them there in an hour and 15, but the altitude sickness effect will be more acute, so be careful (Lima is at sea-level, whilst Cusco is at around 3300 metres!).
Either way, allow a day for travelling and one/two for acclimatising.
Cusco Peru or Cuzco is around 50 minutes of Lima Peru by plane, by bus is around 14 hours.
Cusco has beutiful destins and places for tourist, most of important tourist destination of Peru is in Cusco, if you visit Cusco Peru you can view Sacsayhuaman, Choquequirao, Sacred Valley, Inti Raymi and more fabolous places to visit, if you need more information about travel in cusco Peru, hoteles and guides you can enter to www.cuscocityperu.com and visit cusco Peru on line.