from wikpedia "Selma Blair Beitner in Southfield, Michigan,[1] the daughter of Molly Ann, a judge,[2] and Elliot Beitne"
No they were not related, but they were all prime ministers of England. Update: Tony Blair is not related to either John Major or Margaret Thatcher (Blair is descended from working class...
John Blair owned slaves himself so he was never against slavery.
Actually, John Blair (1731-1800) did have wife. He was married Jean Balfour.My source: http://politicalgraveyard.com/bio/blair.html
he had some sort of sickness (from what i know)