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The expiration date on most drugs tell you when the manufacturer is guaranteeing it will have the maximum potency.

Taking a drug after the expiration date is taking a chance that it won't be as effective as a drug taken within the "guaranteed effective."

So, in answer to your question, on the diphenhydramine, no one knows if it is safe. All you can say for sure, is the manufacturer will not guarantee the drug is 100% effective after the expiration date.

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13y ago
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9y ago

Medication should not be taken past the expiration date. While it is probably safe for quite some time, there is always a chance the ingredients could break down into something bad.

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Q: Is diphenhydramine safe to take after expiration date?
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