Answer:
It might be possible, but you'd need to drill the guitar wood, because humbucking pickups don't fit into the single-coil space because of their size. Another option that you could choose is getting a stacked humbucker, which is, essentially, a single-coil sized humbucking pickup. While it won't sound the same as a real humbucker, it's the closest you can get without having to drill into the precious wood.