Nobody because there is not going to even be a "Spider-Man 4". But there is going to be a reboot called "The Amazing Spider-Man" and he is supposed to be fighting the Lizard (Dr. Curt Connors...
He was bitten by a radioactive spider and it altered his DNA giving him spider-like abilities where he could crawl on walls, jump extremely high, and use spider-sense. Shooting webs from his arms was...