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Is point mutation a frameshift mutation?

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Answer:

Not all point mutations result in a frameshift. However, if the point mutation is an insertion or deletion, then it does result in a frameshift. This occurs because amino acids are coded in nucleotide triplets, and 1 is not evenly divisible by 3.

Consider the following example...

The DNA strand (ACG-GGT-CGA) codes for three amino acids (Threonine, Glycine, Arginine). If an additional nucleobase were randomly inserted, say an additional G (Guanine) anywhere within the strand, the code would shift (ACG-GGG-TCG-A) resulting in a new sequence of amino acids (Threonine, Glycine, Serine). Note: the A to the right is truncated as it does not code for an amino acid.

Most point mutations are substitutions (also known as Single Nucleotide Polymorphisms, or SNPs) and do not result in a frameshift.

First answer by Kevn73. Last edit by Kevn73. Contributor trust: 2 [recommend contributor ]. Question popularity: 3 [recommend question].

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