Um, if i understand your question, no. Jamestown, the first english settlement was found near Norfolk in the Cobham Bay area. If this is not what you are looking for, please reword the question.
Primarily, because place names need not follow rules of grammar. They just have to suggest some 'unique' characteristic.
Nashville
There is no set definition for the number of inhabitants. However, historically, it was any village with some sort of wall.
I'm going to assume you mean early American colonists. They walked, or rode horses or horse drawn carriages.