Answer:
There are several, actually. At least 8 that I'm aware of in various areas of the city. I don't know if you're aware but McDonald's positioning in Latin America is a bit up-scaled versus US (still fast food but prices are not as affordable as the States).
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Now there are much more than 8 because there is at least one in every mall and outside every subway station.
There are McDonald's in:
Av. Baralt
Av. Victoria
Av. Universidad
Bello Monte
CC Victoria Plaza
Centro Plaza
CC Sambil
Chacaito
Chacao
El Paraiso
CC El Recreo
El Valle
La California
La Castellana
La Florida
La Urbina
Las Mercedes
Los Chaguaramos
Macaracuay
Manzanares
Mariches
Parque Central
Prados del Este
Sabana Grande
Plaza Venezuela
CCCT
La Boyera
La Trinidad
La Vizcaya
San Bernardino
Santa Fe
El Recreo
CC Lider
CC Milenium
Tolon Plaza
Victoria Plaza