Answer:
Very doubtful with the grey area of legalites of online gambling in the US.
Take PokerStars the massive online poker site. Some US players who play their (tens's of thousands do) probably presume it to be based in the US. But actually it originally was based in Costa Rica then moved to The Isle of Man in the British Channel Islands in 2005. Neither is PokerStars.com US owned. The Scheinberg family of Israel own and operate it.