Answer:
Xylazine, an alpha-2 agonist, may be reversed using yohimbine. However, it is not reversed every time it is used. Xylazine (also known by the trade name Rompun) frequently wears off quickly enough that reversal is not needed. This would particularly be true if used as an anesthesia pre-medication prior to propofol or thiopental induction. If xylazine is used as the sole anesthestic induction agent, the duration of the procedure would dictate whether or not yohimbine would be necessary. Yohimbine can also be used to reverse xylazine if a patient's heart rate or blood pressure goes down while under anesthesia and a faster recovery is desired. Combining xylazine with an anticholinergic like glycopyrrolate would help prevent the bradycardia associated with xylazine.