It takes two means a couple things and said a couple different ways. It takes two to tango or you can just say it takes two. It usually refers to relationships and how they go wrong and it also refers to making babies.
Yes it is possible but overdosing ibuprofen can cause liver damage. Consult your physician! If you have a large body mass you can usually take higher doses.
You can take a small carry on and a bag you can check. Most of the airlines will charge you for a second bag that you carry on. I was using a small backpack last summer as a carry on and American...