Answer:
Spider-Man's most infamous and dangerous enemies are generally considered to be the Green Goblin, Doctor Octopus, and Venom. Others include Carnage, the Hobgoblin, Electro, the Lizard, Morlun, the Scorpion, the Jackal, Morbius, the Vulture, the Sandman, the Rhino, Kraven the Hunter, Mysterio, the Chameleon, the Kingpin, Hydro-Man, and the Shocker, among many others.
Spider-Man's most renowned rogues include:-
Alistair Smythe
Beetle
Boomerang
Burglar
Carnage
Chameleon
Demogoblin
Doctor Octopus
Lady Octopus
Electro
Green Goblin
Hammerhead
Hobgoblin
Hydro-Man
Kaine
Kingpin
Kraven the Hunter
Jackal
Lizard
Man-Wolf
Molten Man
Morbius
Morlun
Mysterio
Puma
Rhino
Sandman
Scorpion
Shocker
Silvermane
Spencer Smythe
Spider-Slayer
Spot
Swarm
Tinkerer
Tombstone
Venom
Vulture
Foes of lesser renown-
Answer
Armada
Basilisk
Big Wheel
Big Man
Black Tarantula
Black Fox
Calypso
Carrion
Chance
Coldheart
Cyclone
Delilah
Doppelganger
Empathoid
Finisher
Richard Fisk
Foreigner
Vincente "Don" Fortunato
Fusion
Freak
Gog
Grizzly
Grey Goblin
Jonas Harrow
Hitman
Human Fly
Hypertron 1.0
Hypno-Hustler
Iguana
Jack O'Lantern
Kangaroo
Lightmaster
Living Brain
Lobo Brothers
Looter
Jake Martino
Menace
Mindworm
Mirage
Miss Arrow
Mister Negative
Overdrive
Polestar
Queen
Raptor
Ringer
Scream
Scorcher
Scorpia
Screwball
Sentry
Shadrac
Shathra
Shriek
Sin-Eater
Speed Demon
Spidercide
Squid
Stegron
Mendel Stromm
Stunner
Styx and Stone
Tarantula
Tatterdemalion
Thousand
Toro Negro
Tracer
Tri-Sentinel
Seward Trainer
Vermin
Will O' The Wisp
White Rabbit
Wraith