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San francisco to san Diego?

Answer:
Depending traffic it takes about 8 hours to drive from San Francisco to San Diego traveling south on I-5.
It takes approximately 8 hours to drive from San Francisco to San Diego on I-5 (the quickest route).
First answer by Melsandiego. Last edit by Melsandiego. Contributor trust: 14 [recommend contributor recommended]. Question popularity: 1 [recommend question].