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The quickest way to get to Portland, ME from New York City is to take a train to Boston and an Amtrak Thruway Bus to Portland. The bus is available right at Boston's South Station that receives the trains from NYC. Trains with connecting bus service leave NYC at 8:30 am and 12:03 pm and the buses arrive in Portland at 4:10 pm and 6:10 pm, respectively. Coming back, the buses leave Portland at 12:30 pm and 6:00 pm and arrive in Penn Station in NYC at 7:45 pm and 2:20 am (the next day), respectively.

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Q: Train schedule from New York City to Portland Maine?
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