Answer:
For 2010 New Orleans had the highest per capita murder rate of any major city in America, which is the case for the 11th straight year.
2000-N.O. 42.1 D.C. 41.8
2001-N.O. 44.0 Detroit 41.3
2002-N.O. 53.1 D.C. 46.4
2003-N.O. 57.7 D.C. 44.7
2004-N.O. 56.0 Baltimore 43.5
2005-N.O. 44.0 Jan- Aug 31 Baltimore 42.0 Jan-Dec 31
2006-N.O. 76.2 Detroit 47.5
2007-N.O. 81.4 Detroit 45.8
2008-N.O. 55.0 or 64.7 NOPD vs FBI still highest of major cities St. Louis 47.0
2009-N.O. 51.7 St.Louis 42.4
2010-N.O. 49.1 St.Louis 41.2
ADDED: According to May 2011 statistics: FLINT MICHIGAN.