The leader you use has more of an effect on gameplay than the civilization, and the best one depends on what strategy you use when you play. For example, if you want to win by conquest or domination,...
The Harappan civilization stretched from Afghanistan to Bangladesh, and it included north India and Pakistan.
Since there were many earthquakes and floods, it was hard for the Harappan Civilization to grow crops and etc.
the Nile river, Euphrates, Tigris, Indus river and the Hwang He( yellow river )