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What are corneocytes?

Updated: 4/27/2022
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16y ago

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Corneocytes are cells in the stratum corneum, which is the outer skin layer. Corneocytes are stacked to form slightly overlapping columns perpendicular to the skin surface. Individual corneocytes are held together by desmosomes, which bridge adjacent epithelial cells, and by intercellular lipids that seal the space between adjacent cells. The main lipid constituents are cholesterol, free fatty acids, and ceramides. Lipid molecules are covalently bound to the corneocyte membrane and also orient in crystalline multilamellar structures in the intercellular space, forming a tight junction and creating a high resistance to penetration between the cells within the tight clusters.

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16y ago
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