The word 'prefix' does contain a prefix; it is made up from the Latin praefixus (fix in front [of]) + figere (to fasten, to fix), so the 'pre-' part of the word is a prefix.The word 'prefix' itself...
Where the prefix retro- does not merely "reverse" the existing condition (which would already be the opposite e.g. retro-rocket), the opposite would be pro- (proactive, progressive, prograde, and...