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The most common allergic reaction to Vicodin (one brand name of Hydrocodone) is a red rash or a rash with hives (raised bumps in the rash). Another is itching around the nose or legs or slight nausea approximate 15 to 20 minutes after taking the pill.

The main side effect is decrease in respiratory function.

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10y ago
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16y ago

Hives, or rash, throat swelling, difficulty talking or breathing... go to e.r. if you think you are having an allergic reaction to something.

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14y ago

Red eyes, a ton of sneezing. Breakout of hives, etc.

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Q: What are signs of an allergic reaction?
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