Chemicals found in tobacco are over 4,000, but some of the most known are: butane (lighter fluid), ammonia (toilet cleaner), carbon monoxide (car exhaust), and acetone (nail polish remover).
If your question pertains to the species of Nicotiana which are safe to smoke, there are multiple including Nicotiana Tabacum and Nicotiana Rustica - the two most commonly smoked in North America....
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