Antidiabetic drugs.Rosiglitazone (Avandia) and pioglitazone (Actos) are members of the thiazolidinedione class. They act by both reducing glucose production in the liver, and increasing insulin dependent glucose uptake in muscle cells.
It is strongly recommended that all patients treated with pioglitazone or rosiglitazone have regular liver function monitoring.pregnant women should be switched to insulin.It is recommended that...
in 2003, researchers reported that these drugs, which are used by more than 6 million Americans, may lead to serious side effects.some patients developed serious edema and signs of congestive heart...
The drugs are classified as pregnancy category C, based on evidence of inhibition of fetal growth in rats given more than four times the normal human dose.