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Lymphatic filariasis and river blindness, two diseases caused by filarial nematode worms, are the most important human tropical diseases after malaria. Nearly 140 million cases exist and over 1 billion people are at risk for infection. Despite admirable global efforts underway to control these devastating diseases, eradication will be extremely challenging with current technology. No vaccines are available, vector control programs have ended or are facing insect resistance, and drugs are largely ineffective against the worm's adult stage. Current drugs can effectively eliminate the worm's larval stages, but their broad use also increases the likelihood of accelerated drug resistance. To build on the current treatment regimen successes and to ensure that the path towards reduction and elimination of these diseases continues, new classes of chemistry with novel modes of action are urgently needed. The most critical of these are new macrofilaricides (drugs which kill or permanently sterilize the adult nematodes).

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12y ago
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12y ago

your moms worms

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11y ago

ringworm

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Q: What is the worm that mostly causes diseases in humans?
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