Answer:
Climate change can be caused by many things. It's not only nature that changes climate, we too change the climate, our actions changes the whole world so much. These changes are sometimes bad. Our factories cause lots of smoke thus making a hole in the Ozone Layer, when the ozone layer is damaged we will experience more global warming.
Answer:
The ozone layer has no effect on global climate. It does have some effect on the animals that are under the thinning areas of each pole during their winter months, but has no effect on actual weather.
Climate change has been occurring since the beginning of the planet. Currently the planet has been in a warming trend for about 10,200 years. This is caused by know planetary alignments. We see cycles of warming and cooling of the planet that appear to be around 100 thousand years in total cycle times. Warming of the Northern Hemisphere is currently being caused by all major planets being on the same side of our solar system at once. This causes the planet to spin in a very non circular orbit. The effect is referred to as the Milankovich effect, named after the individual that discovered this issue in the early 1900's. In approximately 50K years, the planets will be at maximum dispersion and our orbit the most circular. This will cause lower temps then "normal".
There is also an issue with water flow patterns, wind patterns, and other external variables (solar flares etc.) These all cause variations in our weather and eventually our climate.
Man may also have some contributory effect. The current political belief is that the use of fossil fuels has some effect on the weather (and therefore long term the climate). This is a hotly debated topic despite some political figures claiming the debate to be over. It is know that man contributes about 0.28% of all the annual greenhouse gases emitted into our atmosphere. These gases are what allows the planet to be habitable and retains warmth. It is possible that a portion of the 0.2 to 0.6 degrees of warming the planet has seen since the low portion of the last mini ice age (1850) is attributable to man. This is still an unproven theory and is hotly debated.