During depolarization Na channels are open
During repolarization K channels are open
Neurons undergo depolarization and repolarization when stimulated. The sodium and potassium channels open.
It has to do with what types of channels are open during this phase. In the repolarization phase the number of potassium channels are increased and the number of sodium channels are decreased. This allows for action potentials to not occur. Otherwise, the action potentials would add up and produce tetany.
...repolarization
Fast Calcium
During the depolarization phase, sodium ions enter the cell through the open ion-channels (Na+ influx).
depolarization of the presynaptic membrane due to an arriving action potential
During resting potential, the Sodium-Potassium pump is inactive. Therefore, it is indirectly responsible for the resting potential. However, Potassium diffuses outside the membrane via "leakage" channels, and causes the resting potential.
Inactivation gates of voltage-gated Na+ channels close, while activation gates of voltage-gated K+ channels open.
Action potentials cannot be generated during the absolute refractory period, as not enough ion channels are able to respond to the stimulus, no matter how large it is. Using Na+ fast channels as an example, during depolarization the "gate" of the channel is opened, allowing for Na+ influx into the cell. However, during the repolarization phase, a second "gate" marks the closure of the cell, preventing any further movement of ions into the cell. However, this also means that the channel is unable to open again until the second gate is removed, and the first gate returns back into place.
The action potential has 5 main phases:1) stimulation/rising phase - depolarization caused by influx of sodium ions at the axon hillock; potential increases from a resting potential of -70 mV2) peak phase - depolarization and membrane potential reaches a peak, with sodium channels open maximally, at about +40 mV3) falling phase - potassium channels open in response, causing a subsequent reduction in membrane potential, and the neuron begins to repolarize4) hyperpolarization/undershoot phase - more potassium channels stay open after sodium channels close, causing a hyperpolarization of the neuronal membrane, bringing the potential down below its initial resting potential (below -70 mV)5) refractory phase - potassium channels begin to close, allowing the membrane potential to revert back to the resting potential of -70 mV; during this phase, the probability of the nerve being able to refire is extremely low, thus allowing for a delay between action potentials
Depolarization is the first event in action potential. During depolarization, the sodium gates open and the membrane depolarizes.
On the axon hillock, there is a concentration of sodium channels whose role are to initiate the depolarization and signal transmission allong the axon. Once the all or none threshold is reached, depolarization occurs in a cascade unidirectional along the length of the axon, with potassium channels open just following the sodium-channel mediated depolarization, such that there is no back-propagation of the signal.