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I can think of a couple reasons and I'm sure doctors can come up with even more. Since you didn't go into detail of the feeling it could be Gout. Gout causes very severe pain and inflamation. Even cloths touching the skin around an inflamed joint can cause pain. Also one might consider the possibilities of shingles, which is a virus condition of the nerve endings. It is very painful and even light clothing can cause pain. In either case, talk to a doctor as soon as possible. Please go to the doctor. I had a blood clot in my leg several years ago, and it was red and hot to the touch and extremely painful. When I finally went to the doctor, they couldn't believe I had walked around on it for as long as I did without it dislodging. Because if a blood clot dislodges, it can travel to your brain or your heart and you could die. Please go to the doctor immediately. It is better to be safe than sorry.

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Q: What could be the reason for a leg feeling like it is on fire and clothing hurts it too?
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