This would be easier to answer if you indicated a professional area. For example, if you are a CPA, not many professional organizations would spend time defining "deliberate over-prescribing of controlled substances" as a possible area of gross misconduct for you.
Probably most examples of gross misconduct are exactly that; actions of misconduct that are too large, or too important not to grasp at face value. It is very unlikely that a professional could engage in gross misconduct and not be aware of it.
Emdrgreg