What do you call your sister's daughter?
your sister's daughter= your niece your sister's son= your nephew Your sister's son or daughter would be your nephew or niece respectively.
Your sister's daughter is your niece. You are her aunt (if you are female) or her uncle (if you are male).
Your sister's daughter is your niece, her granddaughter is your "great niece"... or you could just call her by name.
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Your wife's sister's daughter's son (your wife's sister's grandson) is your ( and your wife's) great nephew. The two of you are his great aunt and great uncle.
Your sister's daughter is your niece. You are her aunt (if you are a woman) or her uncle ( if you are a man).