Depending on context, Was ist los can be translated as: What's upWhat's the matter or what's wrong
das ist literally translates to 'that is' you woudl not use it on its own but in a sentance. i.e. Das ist super! That ist super! or Das ist mein hund. That is my dog
Was ist los means can be translated as: "What is wrong?" "What's the matter?" "What's up?"
Ist is the 3rd person singular present indicative of the verb sein, to be. It may also be a prefix, meaning actual, in effect.
"away"
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