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What does a positive Integrated prenatal Screening result mean?
Wiki User
∙ 15y ago
Amniocentesis and CVS, the definitive tests for Trisomy 21 (or Down syndrome), are expensive and not without risk. The Integrated test is a screening test, that divides the population into those at higher risk, and those at lower risk. Usually, from about 2 to 4% of women having the Integrated test will screen positive.
All this means is that they are at a higher risk than was understood prior to the test. By identifying a smaller group of women at higher risk, the costs and risks associated with invasive testing can be restricted to those most likely to be carrying a Down Syndrome fetus. However, the Integrated test is a screen and is not diagnostic; all that can be said about a woman who screens positive is that her risk is higher. Most women who screen positive have normal pregnancies; only a small number actually have Downs fetuses.
Each screening program has its own screening cutoff; the risk at which a woman is deemed to be 'screen positive', so the percentage that actually screen positive (the IPR - Initial Positive Rate) and the OAPR (Odds of being Affected given a Positive Result) vary from program to program. Any woman with a positive result can ask for this information as part of her decision making around further testing.
Wiki User
∙ 15y ago
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