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In more common use decades ago, "Take two aspirin and call me in the morning" was what many patients were told by their doctor, when complaining of a minor malady by telephone. Minor ailments disappeared by the next day. More serious ailments were tended to by the doctor the next day. In general, it's a way of asking or telling someone to refrain from bothering you with trivialities.

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Q: What does take two and call you in the morning mean?
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