Lysis solution usually contains multiple components which will disrupt cellular membranes, inactivate proteins, and stabilize a nucleic acid component.
It dissolves the phospholipid bilayer of cell membranes by forming water-soluble complexes with them. Once the cell membranes are degraded, the cell contents flow out & create a soup of dissolved...
Spermine has four nitrogen in it. Four nitrogen are helpfull to stabilize positive ions from acid. Electron clod on nitrogen takes part actively in order to stabilize positive ions.