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What happens pharmacologically when alcohol is mixed with traditional antidepressants eg cilatopram?
Wiki User
∙ 15y ago
The clearance of alcohol from the body is not affected by citalopram. SSRIs like citalopram work on serotonin- and norepinephrine- synthesizing neurons and slowly cause an increase in the synaptic availability of both of these neurotransmitters. The role of serotonin in the brain is modulatory, i.e., it facilitates the release of other neurotransmitters in cerebral cortex; whereas alcohol is a CNS depressant. It binds to and and opens GABA-gated channels enhancing inhibitory synaptic transmission. Alcohol is therefore counterproductive to the effects of SSRIs - but depending on the amount consumed this may not necessarily a bad thing during the acute phase of SSRI therapy when anxiety is often briefly exacerbated.
Wiki User
∙ 15y ago
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If you have reached a stage when a breakfast 'heart-starter' will help you are hooked. that is your body saying 'where has last nights alcohol gone', the traditional hangover and the traditional 'cure'. If you think you need a starter get help now, it will only get worse , take a walk down skid row and see for yourself. None of us are immune.
