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Nothing, as long as your doctor says you can have either of the medications (i.e. no liver, kidney, or bleeding issues). These medications actually do not interact because they work by different mechanisms in your body.

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16y ago
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15y ago

According to doctors and the poison control center, alternating between ibuprofen (advil, motrin) and acetaminophen (tylenol) is safe in adults, and relatively safe in children. Most doctors and nurse practitioners recommend this practice usually only when a child is fighting a severe fever and is not responding to just one or the other of these OTC medications. The independent dosage amount and timing guidelines still prevail, so read labels carefully. It is recommended that you keep track on paper the time and type (ibupropfen vs. acetaminophen) of dosages you are giving a child to avoid accidentally exceeding the recommended dosage by repeating the same medication as opposed to alternating between the two.

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14y ago

It would depend on your age and weight, and what other medications you are on. In a normal healthy adult of average weight, this would not be an excessive dose. Tylenol and ibuprofen are 2 different drugs.

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14y ago

Yes, I have done it a lot of times. Kidneys can be affected by long term use of Tylenol and the liver can be affected by long term use of Advil (or the generic forms of each you referred to, acetaminophen/ibuprofen) -- but if it's just an occasional situation where you take these OR take them together it is perfectly ok.

It's useful because if one drug helps with one issue and the other drug with another issue it's great when you take them together. Obviously, just no alcohol during this time since Advil/generic is sometimes rough on the stomach and alcohol would make it worse, along with the host of other issues that could happen if you mix the two together.

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11y ago

Taking this pharmaceutical combination is safe and works as well, if not better, than any prescribed pain medication.

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14y ago

No. But three or four will if the pill contains Acetaminophen.

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11y ago

You get pregnant and die.

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Q: Can you mix 2 400mg ibuprofen with 500 mg of acetaminophen?
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Can I take 500 mg. acetaminophen and 200 mg. of ibuprofen together?

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[i heard dont mix ibuprofen and acetaminophen together.neocitran cold and flu contains acetaminophen.] Previous answer is wrong: ibuprofen and acetaminophen are one of the few definitely safe combinations and this is often prescribed by doctors when stronger pain relief is needed. By taking both drugs you avoid having to take too much of either one. You should not, however, mix Ibuprofen with aspirin (acetylsalicylic acid, or ASA) or Naproxen (Aleve). People often mix up acetaminophen and ASA, so read carefully. The problem in answering this question is that there are several different types of neo citran and each contain different combinations of drugs. You have to look at the particular product you purchased and see what drug mix is in it. (i.e., the "cough cold and flu" formula is not the same as "cold and flu" or "total symptom relief." ). You have to check for interactions with all of the components.


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