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Actually it is two: sodium and potassium because they and their regulators are so intertwined. But a very, very simple answer to your question, water always follows sodium.

The principal ions in the ECF are sodium, chloride, and bicarbonate. The ICF contains an abundance of potassium, magnesium, and phosphate ions, plus large numbers of negatively charged proteins.

Despite the differences in the concentration of specific substances, the osmotic concentrations of the ICF and ECF are identical. Osmosis eliminates minor differences in concentration almost at once, because most cell membranes are freely permeable to water.

Sodium is the dominant cation in the ECF (Extra Cellular Fluid)

Potassium is the dominant cation in the ICF (Inter Cellular Fluid).

Two general rules concerning sodium balance and potassium balance are worth noting:

The Most Common Problems with Electrolyte Balance Are Caused by an Imbalance between Gains and Losses of Sodium Ions.

Problems with Potassium Balance Are Less Common, but Significantly More Dangerous than Are Those Related to Sodium Balance.

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6y ago
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10y ago

sodium ions

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11y ago

Sodium.

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Q: What ion plays the largest role in maintaining body fluid volume is?
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