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Acetylcholinesterase, also known as AChE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. It is mainly found at neuromuscular junctions andcholinergic synapses in the central nervous system, where its activity serves to terminate synaptic transmission. AChE has a very high catalytic activity - each molecule of AChE degrades about 25000 molecules of acetylcholine per second. The choline produced by the action of AChE is recycled - it is transported, through reuptake, back into nerve terminals where it is used to synthesize new acetylcholine molecules.
Acetylcholinesterase is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms, which possess similar catalytic properties, but differ in their oligomeric assembly and mode of attachment to the cell surface.
In humans acetylcholinesterase is encoded by the AChE gene.
The chemical compound acetylcholine (often abbreviated ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the motor division of the somatic nervous system. (Sensory neurons use glutamate and various peptides at their synapses.) Acetylcholine is also the principal neurotransmitter in all autonomic ganglia.
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∙ 14y ago
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∙ 11y agoa
destroy ACh a brief period after its release by the axon endings
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∙ 11y agoAn enzyme that breaks down acetylcholine.
Hint: anything ending with "ase" is an enzyme.
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∙ 13y agodestroy ACh a brief period after its release by the axon endings
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∙ 13y agoAcetylcholinesterase is responsible for breaking down acetylcholine in neural synapses
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∙ 9y agoHydrolyze the neurotransmitter acetylcholine, same as it does for every other living thing with a nervous system.
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∙ 12y agoTo break down.
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∙ 12y agoDecompose
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What destroys ACh?
Acetylcholinesterase
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
In the synaptic cleft of a neuromuscular junction what enzyme is always present?
Acetylcholinesterase (AchE)
Mechanism of action of neostigmine?
There are 3 different types of acetylcholinesterase inhibitors - short-acting, medium-duration and irreversible inhibitors, which differ in their interactions with the active site of acetylcholinesterase.=Neostigmine is a medium-duration acetylcholinesterase inhibitor that enhances cholinergic transmission in the central nervous system, autonomic nervous system and at neuromuscular junctions. Acetlycholinesterase inhibitors are an established therapy for Alzheimer's disease and dementia .=
What cleans up chemicals released by nerve cells?
Acetylcholinesterase cleans up chemicals released by nerve cells.
Is there a sentence which includes the word acetylcholinesterase if so what is it?
"Acetylcholinesterase" production results in the production of a glucosteroid inhibitor.
What destroys ACh?
Acetylcholinesterase
What agent inhibits Acetylcholinesterase?
neostigmine
What breaks down acetylcholine?
Acetylcholinesterase
How is acetylcholine (ACh) removed from the synaptic cleft?
Acetylcholine is degraded by acetylcholinesterase
What is the role of acetylcholinesterase to acetylcholine?
The acetylcholinesterase (AChE) essentially works against acetylcholine (ACh). AChE will break up the ACh into its two main groups, acetate and choline so that it is not able to do its job. (In the case of certain diseases, like Alzheimer's, AChE can result in negative effects, and drugs are given to prevent the action of AChE.)
What is the medical abbreviation meaning Acetylcholinesterase?
ACHe
How is acetylcholinesterase dangerous to humans?
Acetylcholinesterase is dangerous to humans as it attacks nerves and causes a loss of use in the affected area. Poisons and venoms contain these properties.
What type of cbrne agent acts by inhibiting a cruicial enzyme called acetylcholinesterase?
Nerve agents are compounds that have the capacity to inactivate the enzyme acetylcholinesterase (AChE)
What has the author John A Montgomery written?
John A. Montgomery has written: 'Standard operating procedures for the determination of acetylcholinesterase activity' -- subject(s): Pesticides, Acetylcholinesterase, Toxicology
What kind of enzyme breaks down acetylcholine?
Acetylcholinesterase
What enzyme is responsible for skeletal muscle relaxation?
acetylcholinesterase
